Gab2 CLIA Kit for Rat(Rattus norvegicus) | EIAab.comGab2 CLIA Kit for Rat(Rattus norvegicus)

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Gab2 (Gene name),

GRB2-associated-binding protein 2 (Protein name ), GAB2_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Gab2;

Protein name:

GRB2-associated-binding protein 2;

Alternative:

Growth factor receptor bound protein 2-associated protein 2;GRB2-associated binder 2;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Interacts with SHC1; may mediate interaction with receptors (By similarity). Interacts with SYK (By similarity). Interacts with PI-3 kinase (By similarity). Interacts with GRB2 (via SH3 2 domain) (By similarity). Interacts with PTPN11 (By similarity). Interacts with TNFRSF11A (via cytoplasmic domain) (By similarity). Interacts (phosphorylated) with 14-3-3 family proteins SFN, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ and YWHAZ; prevents interaction with GRB2 and attenuates GAB2 signaling.

Function:

Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis.

Subcellular Location:

Cytoplasm Cell membrane

Protein Attributes:

Sequence length:

665

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

665:

TDVRQSSEPS | KGAKL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q9EQH1

STRING:

10116.ENSRNOP00000016361

KEGG:

rno:84477

Pfam:

PF00169

UniGene:

Rn.211990

Uniprot:

Q9EQH1

FOR

ELISA Kit for Rat GRB2-associated-binding protein 2

Cat.:

E2740m

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Packing:

96T

ELISA Kit for Rat GRB2-associated-binding protein 2

Cat.:

E2740r

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96T

ELISA Kit for Rat GRB2-associated-binding protein 2

Cat.:

E2740h

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96T

CLIA Kit for Rat GRB2-associated-binding protein 2

Cat.:

U2740m

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Packing:

96T

CLIA Kit for Rat GRB2-associated-binding protein 2

Cat.:

U2740r

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96T

CLIA Kit for Rat GRB2-associated-binding protein 2

Cat.:

U2740h

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Packing:

96T

Polyclonal Antibody for Rat GRB2-associated-binding protein 2

Cat.:

P2740Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat GRB2-associated-binding protein 2

Cat.:

P2740Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat GRB2-associated-binding protein 2

Cat.:

P2740Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Rat GRB2-associated-binding protein 2

Protein for Rat GRB2-associated-binding protein 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Identification of Gab2 as the major molecule responsible for EGF-induced PI3-kinase activation and DNA synthesis in rat hepatocytes."
Kong M. , Mounier C. , Wu J. , Posner B.I.
Submitted (2001-08) to the EMBL/GenBank/DDBJ databases

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